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KMID : 1009020230210030604
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Clinical Psychopharmacology and Neuroscience
2023 Volume.21 No. 3 p.604 ~ p.608
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Successful Early Lamotrigine and Aripiprazole Augmentation of Clomipramine in Severe Obsessive-compulsive Disorder
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Seo Eun-Hyun
Kim Seung-Gon
Lee Jae-Hon
Yoon Hyung-Jun
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Abstract
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Lamotrigine and aripiprazole have shown efficacy as augmentation agents of serotonin reuptake inhibitors for treatment-resistant obsessive-compulsive disorder (OCD). To date, the efficacy of lamotrigine/aripiprazole augmentation has not been reported in OCD treatment. Herein, we report the case of a 37-year-old male with severe OCD and comorbid depression whose symptoms markedly improved after low-dose lamotrigine/aripiprazole augmentation to clomipramine. Our report suggests that early glutamatergic/antipsychotic augmentation contributes to rapid remission of OCD symptoms.
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KEYWORD
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Obsessive-compulsive disorder, Lamotrigine, Aripiprazole, Drug augmentation
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Listed journal information
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